Nene had a strong first half coming off the bench, but he stayed in the locker room after halftime for the Wizards, who entered Tuesday's game without six players already hurting.
Carmelo Anthony couldn't be contained by Otto Porter as he scored 21 points in 25 minutes for the Knicks, who dropped the Wizards to 1-1 in the preseason.
Bradley Beal threw down a big, one-handed dunk in transition over Knicks rookie Kristaps Porzingis.
Rookie Kelly Oubre intends to prove he can crack the Wizards' deep rotation this season (live coverage begins at 6:30 p.m. ET on CSN, CSNmidatlantic.com and NBC Sports Live Extra).
CSN will demo an innovative computer-controlled aerial camera system known as SkyCam at Verizon Center during upcoming Wizards and Capitals games.